Extracting Thermodynamic Parameters from Site-Specific Observables: Chi-Value Analysis
نویسندگان
چکیده
منابع مشابه
Deconstructing thermodynamic parameters of a coupled system from site-specific observables.
Cooperative interactions mediate information transfer between structural domains of a protein molecule and are major determinants of protein function and modulation. The prevalent theories to understand the thermodynamic origins of cooperativity have been developed to reproduce the complex behavior of a global thermodynamic observable such as ligand binding or enzyme activity. However, in most ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.1695